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Frontiers in Endocrinology 2022A number of studies have compared the clinical outcomes between the two endometrial preparation methods: natural cycles (NCs) and hormone replacement treatment (HRT)...
BACKGROUND
A number of studies have compared the clinical outcomes between the two endometrial preparation methods: natural cycles (NCs) and hormone replacement treatment (HRT) before frozen embryo transfer, but the results were conflicting. In order to mitigate the potential effect of embryos per se, several researchers have worked on this subject for euploid blastocyst transfer, but the results were still inconsistent. Therefore, the present study was aimed to investigate the clinical outcomes between HRT and NC for autologous single vitrified-warmed euploid blastocyst transfer based on our data.
METHODS
A total of 598 frozen-thawed single euploid blastocyst transfer cycles in the assisted reproductive center of Northwest Women's and Children's Hospital from January 2014 to May 2021 were retrospectively analyzed. Women were stratified into the NC (n = 125) or HRT (n = 473) group according to the patient's preference and the physician's guidance. Multivariate regression models and subgroup analysis were constructed to analyze the association between endometrial preparation and live birth.
RESULTS
Women in the NC group had a higher live birth rate (68.80% versus 58.35%, = 0.034) and a lower risk of total pregnancy loss (8.51% versus 21.14%, = 0.005) when compared with women in the HRT group. The biochemical pregnancy rate (75.20% versus 74.00%, = 0.784) and clinical pregnancy rate (74.40% versus 69.98%, = 0.334) were similar between the two groups (NC versus HRT). NC was associated with an increased odds of live birth compared with HRT by different multivariable analysis models (Model 1: adjusted odds ratio [aOR], 95% confidence interval [CI]: 0.57, 0.36 - 0.90; Model 2: aOR, 95%CI: 0.57, 0.35 - 0.92). In addition, the increased chance of live birth in the NC group was found in all subgroups. No major obstetrical complications and two malformation livebirths were reported.
CONCLUSIONS
In women undergoing single euploid frozen blastocyst transfers, the NC group was associated with a lower pregnancy loss rate and an ultimately higher live birth rate than the HRT group. Although HRT is convenient for both clinicians and patients, the lower live birth rate should be taken into account and NC might be the first choice of endometrial preparation method.
Topics: Pregnancy; Child; Humans; Female; Birth Rate; Retrospective Studies; Embryo Transfer; Pregnancy Rate; Abortion, Spontaneous; Hormones
PubMed: 36387864
DOI: 10.3389/fendo.2022.969379 -
Asian Journal of Andrology 2022The present study aimed to evaluate the clinical outcomes of magnetic-activated cell sorting (MACS) in sperm preparation for male subjects with a sperm DNA fragmentation...
The present study aimed to evaluate the clinical outcomes of magnetic-activated cell sorting (MACS) in sperm preparation for male subjects with a sperm DNA fragmentation index (DFI) ≥30%. A total of 86 patients who had undergone their first long-term long protocol were selected. The protocol involved in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, and the patients were divided into the MACS or control groups. The MACS group included sperm samples analyzed with MACS that were combined with density gradient centrifugation (DGC) and the swim-up (SU) technique (n = 39), and the control group included sperm samples prepared using standard techniques (DGC and SU; n = 41). No differences were noted with regard to basic clinical characteristics, number of oocytes retrieved, normal fertilization rate, cleavage rate, or transplantable embryo rate between the two groups in IVF/ICSI. In addition, the clinical pregnancy and implantation rates of the first embryo transfer cycles indicated no significant differences between the two groups. However, there was a tendency to improve the live birth rate (LBR) of the first embryo transfer cycle (63.2% vs 53.9%) and the cumulative LBR (79.5% vs 70.7%) in the MACS group compared with the control group. Moreover, the number of transferred embryos (mean ± standard deviation [s.d.]: 1.7 ± 0.7 vs 2.3 ± 1.6) and the transfer number of each retrieved cycle (mean ± s.d.: 1.2 ± 0.5 vs 1.6 ± 0.8) were significantly lower in the MACS group than those in the control group. Thus, the selection of nonapoptotic spermatozoa by MACS for higher sperm DFI could improve assisted reproductive clinical outcomes.
Topics: Birth Rate; DNA Fragmentation; Female; Fertilization in Vitro; Humans; Magnetic Phenomena; Male; Pregnancy; Pregnancy Rate; Semen; Sperm Injections, Intracytoplasmic; Spermatozoa
PubMed: 34708718
DOI: 10.4103/aja202161 -
National Vital Statistics Reports :... Jan 2015This report presents 2013 data on U.S. births according to a wide variety of characteristics. Data are presented for maternal age, live-birth order, race and Hispanic...
OBJECTIVES
This report presents 2013 data on U.S. births according to a wide variety of characteristics. Data are presented for maternal age, live-birth order, race and Hispanic origin, marital status, attendant at birth, method of delivery, period of gestation, birthweight, and plurality. Birth and fertility rates are presented by age, live-birth order, race and Hispanic origin, and marital status. Selected data by mother's state of residence and birth rates by age and race of father also are shown. Trends in fertility patterns and maternal and infant characteristics are described and interpreted.
METHODS
Descriptive tabulations of data reported on the birth certificates of the 3.93 million U.S. births that occurred in 2013 are presented.
RESULTS
A total of 3,932,181 births were registered in the United States in 2013, down less than 1% from 2012. The general fertility rate declined to 62.5 per 1,000 women aged 15-44. The teen birth rate fell 10%, to 26.5 per 1,000 women aged 15-19. Birth rates declined for women in their 20s and increased for most age groups of women aged 30 and over. The total fertility rate (estimated number of births over a woman's lifetime) declined 1% to 1,857.5 per 1,000 women. Measures of unmarried childbearing were down in 2013 from 2012. The cesarean delivery rate declined to 32.7%. The preterm birth rate declined for the seventh straight year to 11.39%, but the low birthweight rate was essentially unchanged at 8.02%. The twin birth rate rose 2% to 33.7 per 1,000 births; the triplet and higher-order multiple birth rate dropped 4% to 119.5 per 100,000 total births.
Topics: Adolescent; Adult; Black or African American; Birth Order; Birth Rate; Birth Weight; Child; Delivery, Obstetric; Ethnicity; Female; Gestational Age; Hispanic or Latino; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Male; Marital Status; Maternal Age; Middle Aged; Multiple Birth Offspring; National Center for Health Statistics, U.S.; Paternal Age; Pregnancy; Pregnancy in Adolescence; United States; Young Adult
PubMed: 25603115
DOI: No ID Found -
Yonsei Medical Journal May 2014Blastocyst transfer has been recommended to raise the implantation rate without affecting the pregnancy rate. The objective of this meta-analysis is to systematically... (Meta-Analysis)
Meta-Analysis Review
Blastocyst transfer ameliorates live birth rate compared with cleavage-stage embryos transfer in fresh in vitro fertilization or intracytoplasmic sperm injection cycles: reviews and meta-analysis.
PURPOSE
Blastocyst transfer has been recommended to raise the implantation rate without affecting the pregnancy rate. The objective of this meta-analysis is to systematically evaluate whether the live birth rate and other pregnancy outcomes can be improved by blastocyst transfer compared with cleavage-stage embryos transfer.
MATERIALS AND METHODS
EMBASE and MEDLINE databases were searched for papers published between March 2004 and March 2013. An extensive range of the electronic databases yielded initially 317 studies from which seven trials met the inclusion criteria for further analysis. Our outcome measures were the live birth rate, clinical pregnancy rate, implantation rate, ongoing pregnancy rate, multiple pregnancy rate, first trimester miscarriage rate and ectopic pregnancy rate. Fixed effects models were chosen to calculate the odds ratio (OR).
RESULTS
Seven trials (n=1446 cases) were finally analyzed. Compared with cleavage-stage embryos transfer, the blastocyst transfer was statistically significantly associated with an increase in clinical pregnancy rate [OR 1.43; 95% confidence interval (CI), 1.15-1.78], implantation rate (OR 1.38; 95% CI, 1.09-1.74) and ongoing pregnancy rate (OR 2.15; 95% CI, 1.57-2.94), and also a reduction in the probability of first trimester miscarriage rate (OR 0.51; 95% CI, 0.30-0.87). The improvement in the live birth rate was also observed (OR 1.77; 95% CI, 1.32-2.37). Moreover, there was no evidence of difference in multiple pregnancy and ectopic pregnancy rates.
CONCLUSION
The available evidences suggest that live birth and other pregnancy outcomes after fresh in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) are significantly improved following blastocyst transfer as compared to cleavage-stage embryo transfer.
Topics: Birth Rate; Embryo Transfer; Female; Fertilization in Vitro; Humans; Pregnancy; Sperm Injections, Intracytoplasmic
PubMed: 24719153
DOI: 10.3349/ymj.2014.55.3.815 -
NCHS Data Brief Sep 2016Data from the National Vital Statistics System •There were 3.978 million births in the United States in 2015, down less than 1% from 2014. •The 2015 U.S. general...
Data from the National Vital Statistics System •There were 3.978 million births in the United States in 2015, down less than 1% from 2014. •The 2015 U.S. general fertility rate (births per 1,000 women aged 15-44) was down 1% from 2014. •Birth rates dropped in 2015 to record lows among women under age 30 and rose for those aged 30-44. •The cesarean delivery rate declined to 32.0% of births in 2015; the preterm birth rate rose slightly to 9.63% from 2014 to 2015. This report presents several key demographic and maternal and infant health indicators using 2015 final birth data. Trends in general fertility rates, age-specific birth rates, cesarean and low-risk cesarean delivery, and preterm birth rates are presented. Data are from the national vital statistics birth files.
Topics: Adolescent; Adult; Birth Rate; Cesarean Section; Female; Humans; Infant, Newborn; Multiple Birth Offspring; Pregnancy; Pregnancy in Adolescence; Premature Birth; United States
PubMed: 27648876
DOI: No ID Found -
Journal of Neurology Oct 2014Association studies form the backbone of biomedical research, with almost every effort in the field ultimately boiling down to a comparison between groups, coupled with... (Review)
Review
Association studies form the backbone of biomedical research, with almost every effort in the field ultimately boiling down to a comparison between groups, coupled with some form of statistical test intended to determine whether or not any observed difference is more or less than would be expected by chance. Unfortunately, although the paradigm is powerful and frequently effective, it is often forgotten that false positive association can easily arise if there is any bias or systematic difference in the way in which study subjects are selected into the considered groups. To protect against such confounding, researchers generally try to match cases and controls for extraneous variables thought to correlate with the exposures of interest. However, if seemingly homogenously distributed exposures are actually more heterogeneous than appreciated, then matching may be inadequate and false positive results can still arise. In this review, we will illustrate these fundamental issues by considering the previously proposed relationship between month of birth and multiple sclerosis. This much discussed but false positive association serves as a reminder of just how heterogeneous even easily measured environmental risk factors can be, and how easily case control studies can be confounded by seemingly minor differences in ascertainment.
Topics: Association; Birth Rate; Case-Control Studies; Confounding Factors, Epidemiologic; Humans; Multiple Sclerosis; Seasons
PubMed: 24413643
DOI: 10.1007/s00415-014-7241-y -
Birth rate among women with fear of childbirth: a nationwide register-based cohort study in Finland.Annals of Epidemiology Mar 2023The association between fear of childbirth (FOC) and subsequent birth rate is not well studied. The aim of this study is to evaluate the birth rate, and risk for second...
PURPOSE
The association between fear of childbirth (FOC) and subsequent birth rate is not well studied. The aim of this study is to evaluate the birth rate, and risk for second pregnancy ending in delivery among women with FOC compared to women without FOC in their first pregnancy.
METHODS
Data from the National Medical Birth Register were used to evaluate the birth rate after the first pregnancy in women with FOC. Cox regression model was used to evaluate the risk for the second pregnancy ending in delivery in women with FOC compared to reference individuals without FOC. The results were interpreted with adjusted hazard ratios (aHRs) and 95% confidence intervals (CI).
RESULTS
In total, 375,619 women were included in this study. Of these, 9660 (2.6%) had FOC in the first pregnancy (exposed group), and 365,959 (97.4%) had no FOC (non-exposed group). In the exposed group, 3600 (37.3%) women had second pregnancy ending in delivery during the study period, and 206,347 (56.4%) had the second pregnancy ending in delivery in the non-exposed group. The risk for the second pregnancy ending in delivery was lower among women with FOC (aHR 0.61, CI 0.59-0.63).
CONCLUSIONS
FOC complicates pregnancy and delivery and is strongly associated with lower likelihood to get pregnant again. Therefore, more research should be focused on the optimal prevention of FOC using a standardized procedure of care and treatment for women with FOC.
Topics: Pregnancy; Female; Humans; Male; Parturition; Cohort Studies; Delivery, Obstetric; Birth Rate; Finland; Fear; Surveys and Questionnaires
PubMed: 36690228
DOI: 10.1016/j.annepidem.2023.01.011 -
NCHS Data Brief Aug 2018This report presents selected highlights from 2017 final birth data on key demographic, health care utilization, and infant health indicators. General fertility rates...
This report presents selected highlights from 2017 final birth data on key demographic, health care utilization, and infant health indicators. General fertility rates (the number of births per 1,000 females aged 15-44 years) and teen birth rates are presented by race and Hispanic origin. The use of Medicaid as the source of payment for the delivery and preterm birth rates are presented by the age of the mother. Data for 2017 are compared with 2016 for each indicator.
Topics: Adolescent; Adult; Birth Rate; Female; Humans; Male; Medicaid; Pregnancy; Pregnancy in Adolescence; Premature Birth; Socioeconomic Factors; United States; Young Adult
PubMed: 30156535
DOI: No ID Found -
Reproductive Health Mar 2022To date, only a few small studies have assessed the effects of major orthopedic traumas on the subsequent birth rate in fertile-aged woman. We assessed the incidences of...
BACKGROUND
To date, only a few small studies have assessed the effects of major orthopedic traumas on the subsequent birth rate in fertile-aged woman. We assessed the incidences of traumatic brain injury (TBI) and fractures of the spine, pelvis, and hip or thigh and evaluated their association with the birth rate in fertile-aged woman.
METHODS
In this retrospective register-based nationwide cohort study, data on all fertile-aged (15-44 years of age) women who sustained a TBI or fracture of the spine, pelvis, hip or thigh between 1998 and 2013 were retrieved from the Care Register for Health Care. A total of 22,780 women were included in TBI group, 3627 in spine fracture group, 1820 in pelvic fracture group, and 1769 in hip or thigh fracture group. The data were subsequently combined with data from the National Medical Birth Register. We used Cox regression model to analyze the hazard for a woman to give birth during 5-year follow-up starting from a major trauma. Women with wrist fractures (4957 women) formed a reference group. Results are reported as hazard ratios (HR) with 95% confidence intervals (CI).
RESULTS
During 5-year follow-up after major trauma, 4324 (19.0%) women in the TBI group, 652 (18.0%) in the spine fracture group, 301 (16.5%) in the pelvic fracture group, 220 (12.4%) in the hip or thigh fracture group, and 925 (18.7%) in the wrist fracture group gave birth. The cumulative birth rate was lower in the hip or thigh fracture group in women aged 15-24 years (HR 0.72, CI 0.58-0.88) and 15-34 years (HR 0.65, CI 0.52-0.82). Women with pelvic fracture aged 25-34 years also had a lower cumulative birth rate (HR 0.79, CI 0.64-0.97). For spine fractures and TBIs, no reduction in cumulative birth rate was observed. Vaginal delivery was the primary mode of delivery in each trauma group. However, women with pelvic fractures had higher rate of cesarean section (23.9%), when compared to other trauma groups.
CONCLUSIONS
Our results suggest that women with thigh, hip, or pelvic fractures had a lower birth rate in 5-year follow-up. Information gained from this study will be important in clinical decision making when women with previous major trauma are considering becoming pregnant and giving birth.
Topics: Adolescent; Adult; Aged; Birth Rate; Cesarean Section; Cohort Studies; Female; Finland; Humans; Pregnancy; Retrospective Studies; Young Adult
PubMed: 35331272
DOI: 10.1186/s12978-022-01387-w -
PloS One 2018The purpose of this study was to explore the factors influencing low birth rate among married women using the National Survey data in Korea. We compared the different...
The purpose of this study was to explore the factors influencing low birth rate among married women using the National Survey data in Korea. We compared the different influences on women's first and subsequent childbirths. This study was a secondary analysis using the "National Survey on Fertility and Family Health and Welfare", which was a nationally representative survey conducted by the Korea Institute for Health and Social Affairs. We analyzed the data of 3,482 married women (aged between 19 and 39 years) using SPSS 20.0 program for descriptive statistics, t-test, one-way ANOVA, and binary and ordinal logistic regression models. The factors influencing women's first childbirth included perceptions about the value of marriage and children and their education level. The factors influencing their subsequent childbirths included multifaceted variables of maternal age during the first childbirth, residential area, religion, monthly household income, perceptions about the value of marriage and children, and social media. It is necessary to improve women's awareness and positive perceptions about marriage and children in order to increase the birth rate in Korea. Moreover, consistently providing financial and political support for maternal and childcare concerns and using social media to foster more positive attitudes toward having children may enhance birth rates in the future.
Topics: Adult; Birth Rate; Employment; Female; Fertility; Humans; Infant, Newborn; Male; Marriage; Maternal Age; Pregnancy; Republic of Korea; Risk Factors; Social Class; Socioeconomic Factors; Young Adult
PubMed: 29558506
DOI: 10.1371/journal.pone.0194597